NIH SBIR: Additional Innovation Funding Lines

  • April 13, 2020

Have an innovation in the healthcare sector? These NIH SBIR funding opportunities may be just the thing to help you commercialize. Below is a summary of the NIH PHS 2019-02 Omnibus Solicitations plus a fairly lengthy list of various NIH SBIR-focused solicitations broken down by focus/topic line, that may be the perfect fit for you.

Total funding support (direct costs, indirect costs, fee) normally may not exceed $252,131 for Phase I awards and $1,680,879 for Phase II awards.

NIH PHS 2019-2 Omnibus Solicitation

Special Announcements for Small Business Research Opportunities | NIH SBIR/STTR

SBIR/STTR Home > Special Announcements for Small Business Research Opportunities Receipt dates for the following Program Announcements (PAs) and Request for Applications (RFAs) may vary. See the NIH Guide for Grants and Contracts for all NIH RFA and PA announcements.

PA-19-273

PA-19-273 is a solicitation for research and development opportunities that include the Center for Disease Control(CDC), Federal Drug Administration(FDA), and National Institute of Health(NIH). This round of funding requires clinical trials. Standard dates apply, so the next round will close April 6th, 2020. See the full solicitation and list of eligible topics here.

PA-19-272

PA-19-272 is a solicitation for research and development opportunities that include the Center for Disease Control(CDC), Federal Drug Administration(FDA), and National Institute of Health(NIH). This round of funding does not accept clinical trials. Standard dates apply, so the next round will close April 6th, 2020. See the full solicitation and list of eligible topics here.

PA-19-271

PA-19-271 is a solicitation for research and development opportunities that include the Center for Disease Control(CDC), Federal Drug Administration(FDA), and National Institute of Health(NIH). This round of funding requires clinical trials. Standard dates apply, so the next round will close April 6th, 2020. See the full solicitation and list of eligible topics here.

PA-19-270

PA-19-270 is a research and development opportunity that does not accept clinical trials. Center for Disease Control(CDC), Federal Drug Administration(FDA), and National Institute of Health(NIH) funding lines are available. Standard due dates apply and the next round will close April 6th, 2020. Read more here.

Memory Impairment

According to NIH, approximately 16 million people in the U.S. suffer from memory loss. Here are some NIH SBIR solicitations for the #smallbusiness that wants to change those statistics.

  • PAR-18-186 Development of Socially-Assistive Robots (SARs) to Engage Persons with Alzheimer’s Disease (AD) and AD-Related Dementias (ADRD), and their Caregivers (R43/R44 Clinical Trial Optional) Due: Apr 05, 2020
  • PAR-18-329 Technology to Detect, Monitor and Assess Daily Functions in Individuals with Cognitive Decline, Alzheimer’s Disease and/or Alzheimer’s Disease-Related Dementias (AD/ADRD) (R43/R44 Clinical Trial Not Allowed) Due: Jan 05, 2020 Award Ceiling: $350,000
  • PAR-18-512 Testing Lifespan/Healthspan-Extension Interventions in the Models of Alzheimers Disease (AD/ADRD) (R43/R44 Clinical Trial Not Allowed) Due Jan 05, 2021 Award Ceiling: $350,000

Mental Health and the Brain/Mind

We often think of the health of the body and diseases associated with the physical body, but there is much work to be done in treating illnesses of the mind and brain. Here are some NIH SBIR opportunities for that topic or related subtopics.

  • PA-18-871 BRAIN Initiative: Development Optimization, and Validation of Novel Tools and Technologies for Neuroscience Research (SBIR) (R43/R44 – Clinical Trial Not Allowed) Due: May 06, 2021
  • PA-18-566 Complex Technologies and Therapeutics Development for Mental Health Research and Practice (R43/R44 Clinical Trial Optional) Due: Jan 05, 2021

Diseases and medication

Here are the NIH SBIR solicitations for the research and prevention of diseases such as HIV and cancer, as well as any solicitations pertaining to the dispensation of medicine.

  • RFA-HL-19-017 NHLBI SBIR Phase IIB Bridge Awards to Accelerate the Commercialization of Technologies for Heart, Lung, Blood, and Sleep Disorders and Diseases (R44 – Clinical Trial Optional) Due: Jul 09, 2020 Award Ceiling: $1,000,000
  • PA-18-928 Innovative Technologies for HIV Behavioral and Social Science Research (R43/R44 Clinical Trial Optional) Due: Sep 05, 2021
  • PAR-18-303 Innovative Molecular Analysis Technology Development for Cancer Research and Clinical Care (R43/R44 Clinical Trial Not Allowed) Due: Jan 07, 2021

Addiction Prevention Services

This country faces a growing opioid epidemic. Alcohol addiction is also a medical issue that warrants research. Here are some NIH SBIR opportunities for substance abuse prevention.

  • PA-18-786 Wearable Alcohol Biosensors (SBIR) (R43/R44- Clinical Trial Optional) Due: Apr 05, 2021
  • RFA-DA-19-019 HEAL Initiative: Americas Startups and Small Businesses Build Technologies to Stop the Opioid Epidemic (R43/R44 – Clinical Trial Optional) Due: Sep 08, 2021

Cellular Studies and Medical Products

Here are NIH SBIR solicitations regarding topics of medical products, or research at a cellular level.

  • PA-18-525 Radiological/Nuclear Medical Countermeasure Product Development Program (SBIR) (R43/R44 Clinical Trial Not Allowed) Due: Jan 05, 2021
  • PA-18-815 Better Defining Growth Medium to Improve Reproducibility of Cell Culture (SBIR) (R43/R44 – Clinical Trial Not Allowed) Due: Apr 05, 2021
  • PA-19-029 Innovation Corps (I-Corps) at NIH Program for NIH and CDC Translational Research (Admin Supp Clinical Trial Not Allowed) Due: Feb 02, 2021
  • PA-18-610 Development of Novel and Emerging Technologies for Cryogenic or Long-term Preservation and Revival of Drosophila and Zebrafish Genetic Stocks (R43/R44 Clinical Trial Not Allowed) Due: Jan 05, 2021

Omnibus or Multi-topic Solicitations

  • PA-18-705 SBIR Technology Transfer (R43/R44 Clinical Trial Not Allowed) Due: Apr 05, 2021
  • PAR-18-618 NINDS Exploratory Clinical Trials for Small Business (R44) – Clinical Trial Required Due: Jan 05, 2021
  • PA-18-631 NIBIB Exploratory Clinical Trials for Small Business (R44 Clinical Trial Required) Due: Jan 05, 2021
  • PA-18-837 Administrative Supplements to Promote Diversity in Small Businesses-SBIR/STTR (Admin Supp Clinical Trial Not Allowed) Due: Sep 04, 2021

The NIH SBIR has so many opportunities for research and development (R&D) of the technology and products being produced by our nation’s small business innovators. You can change the world with one idea. The NIH SBIR program is here to help grow and commercialize the ideas that can lead to a healthier tomorrow. Learn more about NIH SBIR Here.


We work with high-growth startups and organizations that support the startup and innovation ecosystem. We build highly specific non-dilutive funding menus, provide proposal preparation services, and measure outcomes of funding through evaluation. Schedule a consult call with us HERE.

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